Liquid plasma

It is an improved substance for the use in our daily life easily by dissolution of plasma into the water. It can be used for prevention and treatments of various diseases without irritation, so it pays attention as a next generation therapy.


01  Targeted sterilization


  • Sterilization targeting only pathogenic bacteria and viruses without damaging normal cells
  • 99.99% of sterilization effects against 5 pathogenic bacteria including E. coli, Staphylococcus aureus, Salmonella, Bacillus cereus, and Pseudomonas aeruginosa
  • 99.99% of sterilization effects against 5 pathogenic viruses including COVID-19, RSV, RVA, Influenza virus (H1N1), and FCV


* Applicable businesses: general cosmetics, functional cosmetics, consumer chemical products, quasi-drugs, and drugs

* Certified institute: Korea Testing & Research Institute (KTR)

* Test institution: College of Veterinary Medicine, Jeonbuk National University


[Patent application] 

10-2020-0153027


02  Relieve inflammation (acne, atopic dermatitis)


  • Effective for the treatment of acne dermatitis and atopic dermatitis by inhibiting NLRP3 expression which is important for the activation of inflammasome causing inflammation in the skin tissue* Applicable businesses: functional cosmetics, quasi-drugs, and drugs


* Applicable businesses: functional cosmetics, quasi-drugs, and drugs 


[thesis] 

Liquid-type nonthermal atmospheric plasma enhanced regenerative potential of silk-fibrin composite gel in radiation-induced wound failure.

Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin infammatory diseases in NC/Nga mice.

Non-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration.

Opposite effects of non-thermal plasma on cell migration and collagen production in keloid and normal fibroblasts. 

Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination.

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer. Nonthermal plasma induces apoptosis in ATC cells: Involvement of JNK and p38 MAPK-dependent ROS.

[Patent application] 

10-2017-0100291

10-2017-0102295

10-2017-0110764

10-2017-0110760

10-2017-0119293

10-2018-0111159

10-2020-0153027

10-2019-0083818

10-2019-0083817

PCT/KR2017/010234

PCT/KR2017/010235

PCT/KR2018/009700

PCT/KR2018/0010941

16/464,180

16/643,418

16/648,087

16/335,904

16/335,925

14/982,948

[patent registration] 

10-1979105

10-2035458

10-2062320

10-1933920

10-2120552

10537014


03  Tissue regeneration


  • Can be used for the treatments of various tissue damages and cosmetic treatments such as scar, keloid, etc. by facilitating regenerations of tissues, muscle, and blood vessel near the wound area with liquid plasma


* Applicable businesses: quasi-drugs and drugs 


[thesis]

Liquid-type nonthermal atmospheric plasma enhanced regenerative potential of silk-fibrin composite gel in radiation-induced wound failure.

Liquid-type non-thermal atmospheric plasma ameliorates vocal fold scarring by modulating vocal fold fibroblast.

Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin infammatory diseases in NC/Nga mice.

Nonthermal atmospheric plasma enhances myoblast differentiation by eliciting STAT3 phosphorylation.

Non-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration.

Opposite effects of non-thermal plasma on cell migration and collagen production in keloid and normal fibroblasts.

[Patent application] 

10-2017-0100291

10-2017-0110764

10-2017-0110761

10-2021-0108363

PCT/KR2017/010235

PCT/KR2017/012771

PCT/KR2018/009700

16/643,418

16/335,904

10-1979105

10-2035458

10-2062320

10-1933920

10-2120552

10537014

[patent registration] 

10-2035458

10-2006784


04  Wound healing


  • Effective regeneration of various damaged tissues such as wound, pressure sore, burn, etc. by controlling normal cells, inflammatory cells near the wound and their microenvironment


* Applicable businesses: : quasi-drugs, drugs, and medical devices


[thesis]

Liquid-type nonthermal atmospheric plasma enhanced regenerative potential of silk-fibrin composite gel in radiation-induced wound failure.

Liquid-type non-thermal atmospheric plasma ameliorates vocal fold scarring by modulating vocal fold fibroblast.

Opposite effects of non-thermal plasma on cell migration and collagen production in keloid and normal fibroblasts.

[Patent application] 

10-2017-0110764

10-2017-0110761

10-2021-0108363

10-2020-0153027

PCT/KR2017/010235

PCT/KR2017/012771

PCT/KR2018/009700

16/643,418

[patent registration] 

10-2006784


05  Anticancer


  • Decrease the size and mass of cancer tissue by inducing proper active oxygen in the human body with liquid plasma and killing cancer cells selectively without affecting normal cells


* Applicable businesses: medical devices


[thesis]

HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer.

Combination of NTP with cetuximab inhibited invasion/migration of cetuximab-resistant OSCC cells: Involvement of NF-κB signaling.

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer.

Nonthermal plasma induces apoptosis in ATC cells: Involvement of JNK and p38 MAPK-dependent ROS.

Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G(1) arrest via the ATM/p53 pathway.

Non-Thermal Atmospheric Pressure Plasma Inhibits Thyroid Papillary Cancer Cell Invasion via Cytoskeletal Modulation, Altered MMP-2/-9/uPA Activity.

[Patent application] 

10-2020-0153027

10-2015-0153582

14/982,948

[patent registration] 

10-1657063

9750951